COVID-19 Medication Update

SARS-CoV-2 (2019-nCoV) threatens humanity with a pandemic and a collapse of the global economy. Despite the fact that the first manifestations of the virus were seen in 2019, many then did not know about its existence. According to the official version, the virus was transmitted to people from animals, presumably bats. The source of infection was found in Wuhan, Hubei Province, central China. Despite the efforts of the Chinese government, it was not possible to localize the infection. Confirmed infections have already been detected in Australia, North America, and Europe. The virus is easily transmitted and has a high mortality rate.

Coronaviruses are an extensive group of viruses that infect a wide range of animals and humans. In humans, coronaviruses were first discovered as pathogens of a common cold. They were discovered back in the 1980s. in 2002, the world was shocked by an outbreak of severe coronavirus acute respiratory syndrome, SARS with a clinic of rapidly developing pneumonia, respiratory and renal failure. In 2015, the Middle East respiratory syndrome coronavirus MERS appeared in the Middle East, and the year 2019, “pleased” us with a new strain of coronavirus from Wuhan. The clinic of these coronavirus infections is somewhat remotely similar to the extremely severe variant of acute respiratory viral infection – ARVI.

The previous SARS and MERS viruses, although, they were dangerous, but not so infectious, were not so difficult to tolerate and they led to less amount of death.

What about treatment?

Advanced laboratories around the world are working on a drug search. Already managed to decipher the genome of the virus and develop a vaccine, but it still has to pass a series of tests. Scientists tested the effects of existing antiviral agents on 2019-nCoV. There have been found 30 drugs of traditional and alternative medicine, which have a necessary antiviral effect. Among them, there are both, exotic agents that are rarely found and quite popular antiviral drugs.

The recent researches proved that Hydroxychloroquine (Generic Plaquenil)  prevents viral entry into the host cell, lopinavir/ritonavir combination (Generic Kaletra) blocks viral replication.

Reference 1: https://clinicaltrials.gov/ct2/show/NCT04307693
Reference 2: https://docs.google.com/document/d/1SesxgaPnpT6OfCYuaFSwXzDK4cDKMbivoALprcVFj48/mobilebasic

Generic Plaquenil

Plaquenil (Hydroxychloroquine Sulfat)

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