Generic Sovaldi, Sofosbuvir to save on Hepatitis C Treatment
Sovaldi, Sofobusfir drug for effective Hepatitis C treatment
Sofosbuvir 400 mg is an effective medication used for treating Hepatitis C virus when combined with other medications. It is usually combined with drugs like Ribavirin, Ribasphere, and Rebetol, etc. The commercial brand name of Sofobusfir is Sovaldi. Gilead Sciences developed this medicine which was originally manufactured at Pharmasset as PSI-7977. This treatment is far better than its previous counterparts. This remedy has evidently increased the cure rate in HCV infections by reducing a lot of the previous side-effects. The drug has been proved effectual in treating hepatitis c virus by FDA in 2013.
Cost of Sovaldi(Sofobusfir)
The general acquisition cost for Sofosbuvir is $1000 per 400 mg pill and $29 for generic. Therefore, the complete cost of this medication in Hep C genotype 1 for 12-week course is $84000 or 799$ for generic version. And the price increases accordingly for the rising course durations. But Gilead has announced to sell Sofosbuvir in India for approximately $300 per course of treatment. This HCV treatment must only be taken after a genuine doctor prescription.
Numerous experts have argued that most of the patients cannod afford treatment course as the price of Sovaldi is to high:
Where to Buy and how to save on buying?
You can buy the Sovaldi drug for HCV from various online drug pharmacies with a huge discount on its actual price. But if you are purchasing the drug online then make sure to find a trustworthy and legal online pharmacy.
The generic version of Sovaldi is already available. You can check it here –
Generic Sovaldi (Hepcinat)
This life-saving remedy can treat certain types of HCV infection safely and powerfully. The drug is approved for its use in hepatitis genotypes 1, 2, 3 and 4. Treatment method, its duration and recovery entirely depend on the viral genotype. The combinations of the drug and duration of the therapy depend on the genotype.
Working of Hepcinat(Sovaldi)
This new invention in the field of treating hepatitis c infection is a breakthrough. Sovaldi straight away aims for the hepatitis c (Hep C) virus. The combination therapy of its 400 mg dose of another medication is a miraculous cure for the people suffering from Hep C genotypes 1, 2, 3 and 4.
The Hep C virus infects the cells in the liver and produces new copies of it by these cells. A reaction chain of producing such infected cells is set in the liver and collapses it. According to FDA, Sofosbuvir aims this HCV and checks its multiplication. To stop this virus from reproducing, it attaches itself to the genetic information (RNA) in the liver.
Sofosbuvir is a pro-drug that practices approach of pro-tide biotechnology. It activates the anti-viral agent which functions as a malfunctioning substrate for the NS5B protein. This protein is the viral RNA polymerase that performs as an inhibitor of viral RNA synthesis.
Before the advent of this drug, various nucleoside analogs were used for treating Hepatitis C infection. But those pills showed comparatively low potency in the effectual treatment of the disease.
Dosage information:
The recommended dose for an individual as per the doctor prescription is 400 mg per tablet. One tablet should be orally taken daily for recovery from the hepatitis c infection. This prescribed dose of Sofosbuvir should never be skipped. Take the medicine as soon as you remember if you anyhow forget to take it. If you have skipped a day unknowingly, then do not take two doses a day.
For different genotypes of Hepatitis C, the recommended combinations of 400 mg Sovaldi with other drugs vary. The duration of the course for completely rooting out the virus depends on its chronic stage.
GENOTYPE 1 AND 4: – The patients with this genotype of Hepatitis C infection are prescribed the combination of Sovaldi, Peginterferon Alfa and Ribavirin. The course of treatment for this genotype takes 12 weeks. The combined dosage is available at a discount on online pharmacies.
GENOTYPE 2: – The combination of the dose for this genotype is Sofosbuvir with Ribavirin. The whole medication procedure takes 12 weeks.
GENOTYPE 3: – Ribavirin is shared with the medicine for the recommended combination of genotype 3 stage. The duration of drug therapy lasts for 24 weeks.
The patients suffering from Hepatocellular Carcinoma and waiting for liver transplantation must take the combination of Sovaldi and Ribavirin for 48 weeks or until the liver transplantation.
Interaction with other drugs:
The medications that have intestinal P-gp inducers can interact with the HCV treatment. These compounds lower the level of concentrated 400 mg Sofosbuvir. The drugs that are strictly not recommended with this medication regimen are: –
- Anticonvulsants: – These medicines include Phenobarbital, Oxycarbazepine, Carbamazepine and Phenytoin.
- Antimycobacterials: – The linctus under this category is Rifabutin, Rifapentine and Rifampin used in the treatment of tuberculosis.
- Herbal Supplements: – St. John’s Wort or Hypericum Perforatum must not be taken when undergoing this cure.
- Other drugs like Amiodarone, Tipranavir decrease the concentration of the dose and disturb its therapeutic effects.
Source: https://en.wikipedia.org/wiki/Sofosbuvir
Side Effects:
Consuming Sovaldi 400 mg pill may cause common side-effects of an allergic reaction which is otherwise tolerable and effective in its treatment for Hepatitis C. But this cure is sure to benefit the people suffering from Hepatitis C infection. The scheduled courses can overthrow the lethal HCV.
• When Sofosbuvir is used in combination with Ribavirin, it can cause fatigue and headache.
• When it is taken combined with Peginterferon Alfa it results in nausea, difficulty in sleeping and a lower count of RBCs.
• It rarely causes the swelling of the face, lips, tongue or throat in some cases.
• The user may have symptoms of pale skin, light-headed feeling, short-breathe, increased heart-beat rate and concentration problems.
• The list also includes the occurrence of fever, swollen gums, skin sores, cold and cough, mild itching and painful mouth sores.
IMPORTANT SAFETY MEASURES:
There are certain precautionary measures which must be taken care of before undergoing HCV treatment with Sovaldi. You must clearly communicate regarding these below-mentioned details to your healthcare provider: –
• If you have other liver related diseases or had a liver transplantation.
• If you have any severe kidney problem or undergoing dialysis.
• You have HIV or other medical conditions.
• Whether you are pregnant or breastfeeding your baby. The drug is otherwise not known to pass through breast milk.
To sum up:
According to FDA, the recommended 400 mg dose of Sovaldi(Hepcinat), Sofobusfir when consumed in a prescribed manner is a confirmed medication for HCV. There occurs no problem in its purchasing as well because it is available online at decent discounts as well as affordable price of its generic. These discounts make the cost of the treatment much cheaper than the actual price. With little to no side-effects, Sofosbuvir is a new hope in treating this liver-threatening hep c virus.
